@phdthesis{eprintuntirta47144,
            year = {2024},
          school = {FAKULTAS TEKNIK UNIVERSITAS SULTAN AGENG TIRTAYASA},
           title = {SINTESIS EMAS NANOPARTIKEL MENGGUNAKAN BIOREDUKTOR KITOSAN DENGAN METODE SONIKASI SEBAGAI ANTIBAKTERI DAN PROSES ENKAPSULASINYA},
            note = {Luka kronis dan luka bakar saat ini menjadi tantangan serius dalam dunia kesehatan. Luka tersebut sangat rentan terinfeksi oleh bakteri, terutama oleh bakteri seperti Pseudomonas aeruginosa dan Staphylococcus aureus. Ketidakefektifan antibiotik dalam mengobati infeksi luka mendorong para ilmuwan untuk mengembangkan alternatif pengobatan lainnya, seperti sediaan obat berbasis nanoteknologi dalam bentuk salep atau gel. Emas nanopartikel memiliki kelebihan mampu menghambat aktivitas antibakteri karena dapat menembus membran sel 
mikroba dengan mudah sehingga menyebabkan kebocoran isi sel serta kematian mikroba.},
           month = {December},
          author = {ANANDA RIZKY WULANDARI and RINA WATI},
        keywords = {gold nanoparticles, encapsulation, chitosan, sonication, ultrasonicator},
             url = {https://eprints.untirta.ac.id/47144/},
        abstract = {Chronic wounds and burns are currently a serious challenge in the world of health. 
The wound is particularly susceptible to infection by bacteria, especially by bacteria 
such as Pseudomonas aeruginosa and Staphylococcus aureus. The ineffectiveness 
of antibiotics in treating wound infections has encouraged scientists to develop 
other alternative treatments, such as nanotechnology-based drug preparations in the 
form of ointments and gels. Gold nanoparticles have the advantage of being able to 
inhibit antibacterial activity because they can penetrate the microbial cell membrane 
easily, causing leakage of cell contents and microbial death. The purpose of this 
study is to obtain the best chitosan bioreducer volume, optimal synthesis time, 
HAuCl4 concentration and the best chitosan bioreducer concentration in 
synthesizing gold nanoparticles that are able to inhibit bacterial growth and 
characterize chitosan encapsulated gold nanoparticles. The gold nanoparticle 
synthesis in this study uses the sonication method with chitosan as a bioreductor. 
The results obtained showed that the smallest nanoparticle gold size was 180.1 nm 
and the PDI value was 0,433. The optimum conditions for the synthesis of gold 
nanoparticles by sonication method are at 60oC, volume of 5 ml of 2\% chitosan 
bioreductor, concentration of HAuCl4 10 mM and synthesis time of 45 minutes. The 
average inhibition of gold nanoparticles against S. aureus bacteria was 7,99 mm, 
while against P. aeruginosa bacteria was 7,03 mm.}
}