PUTRI, ELVINA AZARIA (2025) HUBUNGAN TERAPI TUBERKULOSIS SENSITIF OBAT DAN TUBERKULOSIS RESISTAN OBAT DENGAN KADAR ENZIM AST DAN ALT DI RSUD BANTEN 2022-2024. S1 thesis, UNIVERSITAS SULTAN AGENG TIRTAYASA.
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Abstract
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Indonesia is one of the countries with the largest number of TB cases. TB cases in Serang City in 2022 were 2,335 cases. Several types of Anti-Tuberculosis Drugs (ATD) have hepatotoxic properties so that the duration of ATD therapy for drug-sensitive tuberculosis (DS-TB) and drug-resistant tuberculosis (DR-TB) can cause side effects in the form of Drug-Induced Hepatitis (DIH) which can be clinically characterized by increased levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes. The purpose of this study was to determine the relationship between the therapy of DS-TB and DR-TB with AST and ALT enzyme levels in tuberculosis patients treated at Banten Regional Hospital in 2022-2024. Methods: This study design used a cross-sectional design. Subjects: Adult patients with TB-SO and TB-RO who underwent ATD therapy and underwent AST and ALT enzyme level examinations at the Banten Regional Hospital laboratory for the period 2022-2024. The sampling technique used was simple random sampling and total sampling with a sample size of 141 patients. The statistical test used was the chi-square test in the form of univariate and bivariate analysis. Results: There is a significant relationship between drug-sensitive tuberculosis and drug-resistant tuberculosis with AST and ALT enzyme levels in Banten Regional Hospital patients 2022-2024. Conclusion: Therapy for drug-sensitive and drug-resistant tuberculosis is associated with increased levels of AST and ALT enzymes.
| Item Type: | Thesis (S1) | |||||||||
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| Additional Information: | Tuberkulosis (TBC) adalah penyakit menular yang disebabkan oleh Mycobacterium tuberculosis. Indonesia menjadi salah satu negara penyumbang terbesar kasus TBC. Di Indonesia, pada tahun 2023, didapat sebanyak 821.200 kasus TBC yang telah terlaporkan. Beberapa jenis obat anti-tuberkulosis (OAT) memiliki sifat hepatotoksisitas sehingga lamanya terapi OAT pada tuberkulosis sensitif obat (TB-SO) maupun tuberkulosis resistan obat (TB-RO) memungkinkan munculnya efek samping berupa Drug Induced Hepatitis (DIH) yang dapat ditandai secara klinis dengan peningkatan kadar enzim aspartat aminotransferase (AST) dan alanin aminotransferase (ALT). Tujuan penelitian ini adalah untuk mengetahui hubungan terapi TB-SO dan TB-RO dengan kadar enzim AST dan ALT pada pasien tuberkulosis yang dirawat di RSUD Banten tahun 2022-2024. Metode: Desain penelitian ini menggunakan desain cross-sectional. Subjek: Pasien dewasa TB-SO maupun TB-RO yang menjalankan terapi OAT dan melakukan pemeriksaan kadar enzim AST dan ALT di laboratorium RSUD Banten periode 2022-2024. Teknik sampling yang digunakan berupa simple random sampling dan total sampling dengan jumlah sampel sebanyak 141 pasien. Uji statistik yang digunakan adalah uji chi square berupa analisis univariat dan bivariat. Hasil: Terdapat hubungan yang signifikan antara tuberkulosis sensitif obat dan tuberkulosis resistan obat dengan kadar enzim AST dan ALT pada pasien RSUD Banten 2022-2024. Kesimpulan: Terapi tuberkulosis sensitif obat dan tuberkulosis resistan obat berhubungan dengan peningkatan kadar enzim AST dan ALT. | |||||||||
| Uncontrolled Keywords: | drug-sensitive tuberculosis (DS-TB), drug-resistant tuberculosis (DR-TB), aspartate aminotransferase (AST) , alanine aminotransferase (ALT) enzymes Tuberkulosis sensitif obat (TB-SO), Tuberkulosis resistan obat (TB-RO), Enzim AST, Enzim ALT | |||||||||
| Subjects: | R Medicine > R Medicine (General) | |||||||||
| Divisions: | 07-Fakultas Kedokteran > 11201-Prodi Kedokteran 07-Fakultas Kedokteran |
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| Depositing User: | Elvina Azaria Putri | |||||||||
| Date Deposited: | 23 Aug 2025 03:21 | |||||||||
| Last Modified: | 23 Aug 2025 03:21 | |||||||||
| URI: | http://eprints.untirta.ac.id/id/eprint/52394 |
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