WULANDARI, ANANDA RIZKY and WATI, RINA (2024) SINTESIS EMAS NANOPARTIKEL MENGGUNAKAN BIOREDUKTOR KITOSAN DENGAN METODE SONIKASI SEBAGAI ANTIBAKTERI DAN PROSES ENKAPSULASINYA. S1 thesis, FAKULTAS TEKNIK UNIVERSITAS SULTAN AGENG TIRTAYASA.
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Abstract
Chronic wounds and burns are currently a serious challenge in the world of health. The wound is particularly susceptible to infection by bacteria, especially by bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. The ineffectiveness of antibiotics in treating wound infections has encouraged scientists to develop other alternative treatments, such as nanotechnology-based drug preparations in the form of ointments and gels. Gold nanoparticles have the advantage of being able to inhibit antibacterial activity because they can penetrate the microbial cell membrane easily, causing leakage of cell contents and microbial death. The purpose of this study is to obtain the best chitosan bioreducer volume, optimal synthesis time, HAuCl4 concentration and the best chitosan bioreducer concentration in synthesizing gold nanoparticles that are able to inhibit bacterial growth and characterize chitosan encapsulated gold nanoparticles. The gold nanoparticle synthesis in this study uses the sonication method with chitosan as a bioreductor. The results obtained showed that the smallest nanoparticle gold size was 180.1 nm and the PDI value was 0,433. The optimum conditions for the synthesis of gold nanoparticles by sonication method are at 60oC, volume of 5 ml of 2% chitosan bioreductor, concentration of HAuCl4 10 mM and synthesis time of 45 minutes. The average inhibition of gold nanoparticles against S. aureus bacteria was 7,99 mm, while against P. aeruginosa bacteria was 7,03 mm.
| Item Type: | Thesis (S1) | ||||||
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| Additional Information: | Luka kronis dan luka bakar saat ini menjadi tantangan serius dalam dunia kesehatan. Luka tersebut sangat rentan terinfeksi oleh bakteri, terutama oleh bakteri seperti Pseudomonas aeruginosa dan Staphylococcus aureus. Ketidakefektifan antibiotik dalam mengobati infeksi luka mendorong para ilmuwan untuk mengembangkan alternatif pengobatan lainnya, seperti sediaan obat berbasis nanoteknologi dalam bentuk salep atau gel. Emas nanopartikel memiliki kelebihan mampu menghambat aktivitas antibakteri karena dapat menembus membran sel mikroba dengan mudah sehingga menyebabkan kebocoran isi sel serta kematian mikroba. | ||||||
| Uncontrolled Keywords: | gold nanoparticles, encapsulation, chitosan, sonication, ultrasonicator | ||||||
| Subjects: | Q Science > Q Science (General) Q Science > QR Microbiology R Medicine > R Medicine (General) R Medicine > RL Dermatology R Medicine > RM Therapeutics. Pharmacology T Technology > TP Chemical technology |
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| Divisions: | 03-Fakultas Teknik > 24201-Jurusan Teknik Kimia | ||||||
| Depositing User: | Ananda Rizky Wulandari | ||||||
| Date Deposited: | 19 Feb 2025 00:57 | ||||||
| Last Modified: | 19 Feb 2025 00:57 | ||||||
| URI: | http://eprints.untirta.ac.id/id/eprint/47144 |
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