Damayanti, Marshavina (2024) Hubungan Profil D-dimer Terhadap Tingkat Keparahan Stroke Iskemik Teritori di Rumah Sakit Umum Daerah Banten. S1 thesis, Universitas sultan ageng tirtayasa.
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Abstract
Ischemic stroke become the most common cause of mortality and disability for elderly in Indonesia. Territorial ischemic stroke are often associated with the presence of blood clots that clog blood vessels in the brain. There were somehow association in different studies between increased levels of d-dimer as a fibrinolysis factor and the severity of territorial ischemic stroke which evaluated by using National Institutes of Health Stroke Scale (NIHSS) scores. This study aimed to analyze the association of d-dimer profile to the severity of territorial ischemic stroke. A Cross sectional study was conducted by taking secondary data retrospectively through medical records at the Medical Record and Radiolgy Installation at Banten Regional Public Hospital. D-dimer profile was categorized with a cutoff point 1000 ng/mL and NIHSS score was categorized with a cutoff point 10. The statistical analysis test used in this study was Fischer Exact Test. Forty-One of territorial ischemic stroke patients data were included in this study. Territorial ischemic stroke patients were mostly in the age group of 51—60 years with 16 patients (39%), males with 22 patients (53,7%), education in elementary school with 14 patients (34,1%), and territorial ischemic at left brain hemisphere precisely on frontal lobe with 14 patients (34,1%), temporal lobe with 15 patients (36,6%), and parietal lobe with 15 patients (36,6%). There was statistically significant association (p = 0,016) between the d-dimer profile and severity of territorial ischemic stroke (OR 9,6; 95% CI (1,5—60,6)). Early abnormal d-dimer levels on admission cause worsening of the condition in patients with territorial ischemic stroke based on NIHSS scores.
| Item Type: | Thesis (S1) | |||||||||
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| Additional Information: | Latar Belakang Stroke iskemik menjadi penyebab kematian dan disabilitas yang umum ditemukan pada usia tua di Indonesia. Stroke iskemik teritori dikaitkan dengan adanya bekuan darah yang menyumbat pembuluh darah di otak. Terdapat hubungan antara peningkatan kadar d-dimer sebagai faktor fibrinolisis dengan tingkat keparahan stroke iskemik teritori pasien yang dievaluasi menggunakan skor National Institue of Health Stroke Scale (NIHSS) pada beberapa studi yang berbeda. Penelitian ini bertujuan untuk menganalisis hubungan profil d-dimer terhadap tingkat keparahan stroke iskemik teritori. Metode Penelitian potong lintang dengan pengambilan data sekunder secara retrospektif melalui rekam medis di Instalasi Rekam Medis dan Instalasi Radiologi Rumah Sakit Umum Daerah Banten. Profil D-dimer dikategorikan dengan nilai potong 1.000 dan skor NIHSS dikategorikan dengan nilai potong 10. Uji analisis statistik yang digunakan pada penelitian ini adalah Uji Fischer exact. Hasil Sebanyak 41 data pasien stroke iskemik teritori yang diinklusi dalam penelitian. Pasien stroke iskemik teritori sebagian besar berada pada kelompok usia 51—60 tahun sebanyak 16 pasien (39%), laki-laki sebanyak 22 pasien (53,7%), tamatan sekolah dasar sebanyak 14 pasien (34,1%), dan teritori iskemik pada hemisfer kiri otak, tepatnya lobus frontal sebanyak 14 pasien (34,1%), lobus temporal sebanyak 15 pasien (36,6%), dan lobus parietal sebanyak 15 pasien (36,6%). Dari hasil uji fischer didapatkan bahwa terdapat hubungan yang signifikan secara statistic (p=0,016) antara profil d-dimer dan tingkat keparahan stroke iskemik teritori (OR 9,6; IK95% (1,5—60,6)). Kesimpulan Kadar d-dimer yang abnormal pada awal admisi menyebabkan perburukan kondisi penderita stroke iskemik teritori berdasarkan skor NIHSS. | |||||||||
| Uncontrolled Keywords: | D-dimer Levels, NIHSS, Territorial Ischemic Stroke, Kadar D-dimer, NIHSS, Stroke iskemik teritori | |||||||||
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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| Divisions: | 07-Fakultas Kedokteran > 11201-Prodi Kedokteran 07-Fakultas Kedokteran |
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| Depositing User: | Marshavina Damayanti | |||||||||
| Date Deposited: | 15 Jul 2024 12:57 | |||||||||
| Last Modified: | 15 Jul 2024 12:57 | |||||||||
| URI: | http://eprints.untirta.ac.id/id/eprint/37832 |
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