Intania Meilan Putri, Sheva and Belgis Helmalia Hasanah, Ratu (2023) PEMBUATAN CANGKANG KAPSUL ALGINAT-KITOSAN DENGAN METODE CROSSLINK SEBAGAI SISTEM PENGHANTAR OBAT. S1 thesis, UNIVERSITAS SULTAN AGENG TIRTAYASA.
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Abstract
In general, the manufacture of capsule shells uses animal gelatin as raw material, which is feared to cause several animal diseases to humans. Beef gelatin is at risk of being contaminated with several viruses, while pork gelatin is a problem for the people of Indonesia, who are predominantly Muslim. Therefore, it is necessary to have alternative raw materials that can overcome the shortage of gelatin. Raw materials that can be used as an alternative are polysaccharides, one of the polysaccharides that can be used as a substitute for gelatin in drug delivery systems is chitosan and alginate. The purpose of this study was to determine the characteristics and effect of variations of alginate-chitosan capsules made using the crosslink method and to determine the disintegration time of alginate-chitosan capsule shells in artificial intestinal and gastric fluids. The method used in this study began with making polysaccharide solutions, namely chitosan and alginate, then printed with a capsule printing tool, then cross-linked with their respective crosslinkers, namely NaTPP, and CaCl2.H2O, then characterization tests were carried out with SEM, XRD, and FTIR. The results of this study were the formation of a capsule shell of the alginate- CaCl2.H2O variety. The results of the characterization test by SEM for Chitosan-NaTPP showed a homogeneous and porous surface, while the results of the SEM test for Alginate- CaCl2.H2O showed a solid and dense surface. The results of the FTIR analysis showed that there was an interaction between chitosan and NaTPP and alginate with CaCl2, and the results of the XRD analysis showed that peaks occurred at several positions, namely 14.3°, 21°, 29°, 30°, and 39°. So, the capsule shell made with alginate using the crosslink method has good shell characteristics.
| Item Type: | Thesis (S1) | ||||||
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| Additional Information: | Secara umum, pembuatan cangkang kapsul menggunakan bahan baku gelatin hewani, yang dikhawatirkan dapat menimbulkan beberapa penyakit hewan kepada manusia. Gelatin sapi berisiko terkontaminasi beberapa virus sedangkan gelatin babi menjadi masalah bagi masyarakat Indonesia yang mayoritasnya beragama islam. Oleh karena itu, perlu adanya alternatif bahan baku yang dapat mengatasi kekurangan gelatin tersebut. Bahan baku yang dapat digunakan sebagai alternatif yaitu polisakarida, salah satu polisakarida yang dapat digunakan sebagai pengganti bahan gelatin pada drug delivery system adalah kitosan dan alginat. Tujuan penelitian ini adalah mengetahui karakteristik dan pengaruh variasi kapsul alginat-kitosan yang dibuat dengan metode crosslink serta mengetahui waktu hancur cangkang kapsul alginat-kitosan pada cairan usus dan lambung buatan. Metode yang digunakan dalam penelitian ini diawali dengan membuat larutan polisakarida yaitu kitosan dan alginat, kemudian dicetak dengan alat cetak kapsul, lalu ditaut silang dengan crosslinker-nya masing-masing yaitu NaTPP, dan CaCl2.H2O, selanjutnya dilakukan pengujian karakterisasi dengan SEM, XRD, dan FTIR. Hasil dari penelitian ini adalah terbentuknya cangkang kapsul variasi alginat-CaCl2.H2O. Hasil uji karakterisasi dengan SEM untuk Kitosan-NaTPP menunjukkan permukaan yang homogen dan berpori, sementara hasil uji SEM untuk Alginat- CaCl2.H2O menunjukan adanya permukaan padat dan rapat. Hasil analisis FTIR menunjukkan bahwa terjadinya interaksi antara kitosan dengan NaTPP serta alginat dengan CaCl2, dan hasil analisa XRD menunjukkan peak yang terjadi pada beberapa posisi yaitu 14.3°, 21°, 29°, 30°, dan 39°. Jadi, cangkang kapsul yang dibuat dengan bahan alginat menggunakan metode crosslink memiliki karakteristik cangkang yang baik. | ||||||
| Uncontrolled Keywords: | Alginat, Cangkang Kapsul, Crosslink, Gelatin, Kitosan | ||||||
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
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| Divisions: | 03-Fakultas Teknik 03-Fakultas Teknik > 24201-Jurusan Teknik Kimia |
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| Depositing User: | Mrs Sheva Intania Meilan Putri | ||||||
| Date Deposited: | 24 Jul 2023 09:54 | ||||||
| Last Modified: | 27 Jul 2023 10:10 | ||||||
| URI: | http://eprints.untirta.ac.id/id/eprint/27094 |
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